The Callisto Protocol - is a single-player third-person survival horror game.

The main character, Jacob Lee, ends up on Jupiter's moon Callisto, where a prison is located. The prisoners are infected with an unknown disease that turns them into monsters.

The player needs to understand what is happening and get out of there. For this purpose, he can interact with other characters, as well as collect and listen to audio recordings with information necessary to understand the events and the situation. In addition, these records contain clues necessary for survival.

To destroy enemies, you can use firearms, as well as hand-to-hand combat techniques. Jacob's health is monitored by a special implant on his neck, and it can be restored with the help of special injections.